Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS) (2024)

Lee, C. H., Sugiyama, T., Kataoka, A., Kudo, A., Fujino, F., Chen, Y. W., Mitsuyama, Y., Nomura, S., & Yoshioka, T. (2013). Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). PLoS ONE, 8(10), 文章 e75360. https://doi.org/10.1371/journal.pone.0075360

Lee, Chih Hung ; Sugiyama, Takashi ; Kataoka, Aiko 等. / Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). 於: PLoS ONE. 2013 ; 卷 8, 編號 10.

@article{161ecdb7e592425298b4953aa9d4a181,

title = "Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS)",

abstract = "Pain and itch are closely related sensations, yet qualitatively quite distinct. Despite recent advances in brain imaging techniques, identifying the differences between pain and itch signals in the brain cortex is difficult due to continuous temporal and spatial changes in the signals. The high spatial resolution of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) has substantially advanced research of pain and itch, but these are uncomfortable because of expensiveness, importability and the limited operation in the shielded room. Here, we used near infrared spectroscopy (NIRS), which has more conventional usability. NIRS can be used to visualize dynamic changes in oxygenated hemoglobin and deoxyhemoglobin concentrations in the capillary networks near activated neural circuits in real-time as well as fMRI. We observed distinct activation patterns in the frontal cortex for acute pain and histamine-induced itch. The prefrontal cortex exhibited a pain-related and itch-related activation pattern of blood flow in each subject. Although it looked as though that activation pattern for pain and itching was different in each subject, further cross correlation analysis of NIRS signals between each channels showed an overall agreement with regard to prefrontal area involvement. As a result, pain-related and itch-related blood flow responses (delayed responses in prefrontal area) were found to be clearly different between pain (τ = +18.7 sec) and itch (τ = +0.63 sec) stimulation. This is the first pilot study to demonstrate the temporal and spatial separation of a pain-induced blood flow and an itch-induced blood flow in human cortex during information processing.",

author = "Lee, {Chih Hung} and Takashi Sugiyama and Aiko Kataoka and Ayako Kudo and f*ckue Fujino and Chen, {Yu Wen} and Yuki Mitsuyama and Shinobu Nomura and Tohru Yoshioka",

year = "2013",

month = oct,

day = "3",

doi = "10.1371/journal.pone.0075360",

language = "英语",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

number = "10",

}

Lee, CH, Sugiyama, T, Kataoka, A, Kudo, A, Fujino, F, Chen, YW, Mitsuyama, Y, Nomura, S & Yoshioka, T 2013, 'Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS)', PLoS ONE, 卷 8, 編號 10, e75360. https://doi.org/10.1371/journal.pone.0075360

Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). / Lee, Chih Hung; Sugiyama, Takashi; Kataoka, Aiko 等.
於: PLoS ONE, 卷 8, 編號 10, e75360, 03.10.2013.

研究成果: 期刊稿件 › 文章 › 同行評審

TY - JOUR

T1 - Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS)

AU - Lee, Chih Hung

AU - Sugiyama, Takashi

AU - Kataoka, Aiko

AU - Kudo, Ayako

AU - Fujino, f*ckue

AU - Chen, Yu Wen

AU - Mitsuyama, Yuki

AU - Nomura, Shinobu

AU - Yoshioka, Tohru

PY - 2013/10/3

Y1 - 2013/10/3

N2 - Pain and itch are closely related sensations, yet qualitatively quite distinct. Despite recent advances in brain imaging techniques, identifying the differences between pain and itch signals in the brain cortex is difficult due to continuous temporal and spatial changes in the signals. The high spatial resolution of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) has substantially advanced research of pain and itch, but these are uncomfortable because of expensiveness, importability and the limited operation in the shielded room. Here, we used near infrared spectroscopy (NIRS), which has more conventional usability. NIRS can be used to visualize dynamic changes in oxygenated hemoglobin and deoxyhemoglobin concentrations in the capillary networks near activated neural circuits in real-time as well as fMRI. We observed distinct activation patterns in the frontal cortex for acute pain and histamine-induced itch. The prefrontal cortex exhibited a pain-related and itch-related activation pattern of blood flow in each subject. Although it looked as though that activation pattern for pain and itching was different in each subject, further cross correlation analysis of NIRS signals between each channels showed an overall agreement with regard to prefrontal area involvement. As a result, pain-related and itch-related blood flow responses (delayed responses in prefrontal area) were found to be clearly different between pain (τ = +18.7 sec) and itch (τ = +0.63 sec) stimulation. This is the first pilot study to demonstrate the temporal and spatial separation of a pain-induced blood flow and an itch-induced blood flow in human cortex during information processing.

AB - Pain and itch are closely related sensations, yet qualitatively quite distinct. Despite recent advances in brain imaging techniques, identifying the differences between pain and itch signals in the brain cortex is difficult due to continuous temporal and spatial changes in the signals. The high spatial resolution of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) has substantially advanced research of pain and itch, but these are uncomfortable because of expensiveness, importability and the limited operation in the shielded room. Here, we used near infrared spectroscopy (NIRS), which has more conventional usability. NIRS can be used to visualize dynamic changes in oxygenated hemoglobin and deoxyhemoglobin concentrations in the capillary networks near activated neural circuits in real-time as well as fMRI. We observed distinct activation patterns in the frontal cortex for acute pain and histamine-induced itch. The prefrontal cortex exhibited a pain-related and itch-related activation pattern of blood flow in each subject. Although it looked as though that activation pattern for pain and itching was different in each subject, further cross correlation analysis of NIRS signals between each channels showed an overall agreement with regard to prefrontal area involvement. As a result, pain-related and itch-related blood flow responses (delayed responses in prefrontal area) were found to be clearly different between pain (τ = +18.7 sec) and itch (τ = +0.63 sec) stimulation. This is the first pilot study to demonstrate the temporal and spatial separation of a pain-induced blood flow and an itch-induced blood flow in human cortex during information processing.

UR - http://www.scopus.com/inward/record.url?scp=84884853968&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0075360

DO - 10.1371/journal.pone.0075360

M3 - 文章

C2 - 24098378

AN - SCOPUS:84884853968

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 10

M1 - e75360

ER -

Lee CH, Sugiyama T, Kataoka A, Kudo A, Fujino F, Chen YW 等. Analysis for Distinctive Activation Patterns of Pain and Itchy in the Human Brain Cortex Measured Using Near Infrared Spectroscopy (NIRS). PLoS ONE. 2013 10月 3;8(10):e75360. doi: 10.1371/journal.pone.0075360